How to Avoid Altitude sickness during Nepal trek?

Because of the lack of oxygen, firstly as a syndrome acute mountain sickness, its pre-sign of High altitude sickness. Syndrome such as a headache, insomnia, dizziness, fatigue, nausea, and vomiting.
Second: the more serious stage is high-­altitude cerebral edema, also known as HACE, brain swelling that is potentially fatal.

Lack of oxygen can directly damage brain cells, since in unconscious. The walls of blood capillaries begin to leak at high altitudes when we push up in high, and the leaked fluid can cause dangerous swelling, pressing the brain outward against the rigid skull. Whereas optic nerves swell so badly they bulge into the back of the eye, degrading vision and causing retinal hemorrhages.
Manaslu circuit trek High altitude map


The Severe cases of acute high-altitude disease have long been known to cause brain damage. The sobering things about the Fayed study are that even when climbers showed no signs of acute sickness, the scans still found brain damage. There are some finding such as cortical atrophy or enlargement of the Virchow-Robin (VR) spaces. Moreover, amateur climber’s brain also found suffered subcortical lesions in the frontal lobes.

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